Time to take out the trash.
From every cell in your body.
High potency spermidine: 20 mg per serving, at or above the dose in the major longevity studies, 99+% pure.
- Linked to nearly 6 years of longer life
- The highest dose of pure spermidine in any leading brand
- In a 90-day human study, more hair in its growth phase
30-days to get a FULL refund on prepaid 12-month subscriptions
See the results in your bloodwork or don't pay
FREE SHIPPING IN THE US
Double the spermidine of 4 out of the 5 top-selling competitors tested. See every result
Label says 20 mgTested 21.9 mg
Current batch · Lot S26238002 Download (PDF)
SEE THE RESULTS IN YOUR BLOODWORK OR DON'T PAY
Take SPMD-99 for 4 months, with a blood test at the beginning and blood test at the end. If you don't see an improvement in biomarkers, tell us and you'll get a full refund.
Full refund within 180 days for any reason. (For prepaid annual subscriptions, due to deep discount, full refund only within 30 days of receiving first shipment.)
- Test before you start
- Every day for 4 months
- Test again at 4 months
- Before your first capsule
Run a panel with immune markers, so you can measure the change later.
- Every day
The deeper cleanup happens inside your cells, where you won't feel most of it.
- Around 90 days
More hair follicles back in active growth, with stronger nails and firmer skin.
- 4 months and beyond
Run the same panel again, and keep going.
Start with 1 capsule daily with food, then move to 2 after a few days. Up to two servings a day.
SPMD-99
The blood tests for SPMD-99
Get these before you start, then again after 4 months, from the same lab both times. Your doctor can order them, or you can order most of them yourself from Quest or Labcorp.
- hs-CRP: lower is better.The standard blood test for inflammation.
- Hemoglobin A1c: lower is better.Your average blood sugar over the last three months, in one number.
- Fasting glucose and fasting insulin: lower is better.How well your body handles sugar.
- LDL cholesterol: lower is better.The "bad" cholesterol. It builds up in your arteries.
- HDL cholesterol: higher is better.The "good" cholesterol. It carries the extra back to your liver.
- Triglycerides: lower is better.The main fat in your blood.
- White blood cell count: lower is better.Your immune cells. They're on a standard CBC blood test.
If your numbers haven't improved after 4 months, just email hello@opus.life, and we'll refund everything you paid.
Full refund within 180 days for any reason. (For prepaid annual subscriptions, due to deep discount, full refund only within 30 days of receiving first shipment.)
Linked to nearly 6 years of longer life.
Population study. Researchers followed 829 people aged 45 to 84 in Bruneck, Italy, for 20 years and compared their intake of 146 compounds. Spermidine had the strongest link to a longer life of any nutrient measured: nearly 6 more years.
Inside every cell, the junk is piling up.
Worn out proteins. Broken machinery. Cellular debris that accumulates faster every year you are alive. Fasting is the famous way to clear it. But autophagy slows with age, and the junk it once cleared piles up.
Your cells think you’re fasting.
Your body produces spermidine for one reason: to launch autophagy. The deep cellular cleanup that hunts down every piece of debris piling up inside your cells, and destroys it.
It activates the exact same renewal pathways as a prolonged fast. Every cell gets the signal to strip out the old, the broken, the spent, and rebuild from scratch.
No hunger. No deprivation. The full power of fasting, from a molecule your body already knows.
Pure spermidine, not extract.
Most spermidine supplements fill a big capsule with wheat germ extract, which is approximately 1% purity and varies from batch to batch. SPMD-99 is the pure molecule, 99+% purity, verified lot by lot.
Clean label: only 3 ingredients. Plant-based capsules containing spermidine, organic acacia fiber and organic rice hulls. That is the whole list.
Independent lab tests
Double the spermidine of 4 out of the 5 top-selling competitors tested.
We bought the 5 top-selling spermidine supplements online and had them shipped directly to an independent 3rd-party lab. The lab tested each one alongside SPMD-99, and you can download every report.
| Product | Tested |
|---|---|
 |
21.9 mgLab report |
| Renue By Science Liposomal SpermidineLabel says 8 mg | 19.0 mgLab report |
| Nutricost Spermidine Wheat Germ ExtractLabel says 15 mg | 11.0 mgLab report |
| Double Wood Spermidine 10 mgLabel says 10 mg | 10.4 mgLab report |
| OMRE Spermidine Wheat Germ ExtractLabel says 10 mg | 9.4 mgLab report |
| Longevity Labs spermidineLIFELabel gives no spermidine amount | 0.7 mgLab report |
One of the 5 top-selling brands, Longevity Labs spermidineLIFE, uses wheat germ and doesn't say on its label how much spermidine is inside. It delivered 0.7 mg.
6 ways SPMD-99 works for you.
Longevity
Spermidine ranked #1 of 146 compounds for its link to a longer life.
Autophagy without fasting
Spermidine triggers autophagy, the cellular cleanup fasting is famous for, without skipping a meal.
(Hofer et al., 2024; Alsaleh et al., 2026; Alsaleh et al., 2020)
Hair, skin and nails
In a placebo-controlled study, spermidine drove significantly more hair follicles back into their active growth phase. The same renewal drives collagen production and strengthens the moisture barrier that keeps skin firm and elastic, and builds dense, resilient nails. Fuller hair, stronger nails, firmer skin, one molecule behind all of it.
(Rinaldi et al., 2017; Ramot et al., 2011; Marzani et al., 2018)
Heart
Spermidine helps keep your hardest-working muscle running strong. Higher intake tracks with healthier hearts across population studies.
(Kiechl et al., 2018; Han et al., 2024; Eisenberg et al., 2016)
Brain
Spermidine crosses the blood-brain barrier and clears the toxic protein buildup that clouds thinking and memory.
(Wirth et al., 2018; Schroeder et al., 2021; Qian et al., 2024)
Immunity
In a recent clinical study spermidine reversed declining immune function and reduced chronic inflammation.
(Alsaleh et al., 2026; Alsaleh et al., 2020; Zhang et al., 2019)
You need help cleaning up the microplastics.
Microplastics have been detected in the blood of 77% of healthy adults. Based on recent research, you are likely carrying about 7 grams of microplastics in your brain: the weight of a plastic spoon.
When your cells detect nanoplastics, they try to clear them using autophagy. But plastics jam the system. The recycling machinery stalls, mitochondria get damaged, and inflammation spikes.
Spermidine keeps the autophagy going, isolating the plastic particles and continuing the cleanup. It also triggers mitophagy, clearing the damaged mitochondria so they don’t sap your energy.
Spermidine and sulforaphane are two of the only supplements shown to help remove microplastics from the body.
The average person ingests about 20 grams of microplastics every month, the weight of a one-liter water bottle.
Senathirajah and Palanisami, University of Newcastle, Australia, 2019. No Plastic in Nature: Assessing Plastic Ingestion from Nature to People, commissioned by WWF.
Made right, in California.
Every ingredient and every milligram on the Supplement Facts panel.
Supplement Facts
Serving Size: 2 Capsules
Servings per container: 30
| Amount per serving | %DV | |
|---|---|---|
| Spermidine 3HCl | 20mg | ** |
** Daily Value Not Established
SPMD-99 is produced in California, in a highly advanced FDA registered facility with GMP certification from NSF, UL and the Natural Products Association, as well as organic and Non-GMO certifications. Independently lab tested for purity and potency.
Made without Milk, Eggs, Nuts, Crustaceans, Shellfish, Wheat, Soy and Sesame.
Everything else on the label
What makes SPMD-99 more effective than any other spermidine supplement you can buy?
Spermidine may be the single most powerful nutrient for living longer. It activates autophagy, the cellular process that makes fasting extend lifespan.
In a landmark 20-year study comparing 146 compounds, spermidine had the strongest link to a longer life, equivalent to nearly six additional years of lifespan.
Most spermidine supplements are wheat germ extract, delivering as little as 1mg per serving, along with gluten, allergens, and batch-to-batch variation.
SPMD-99 is pure spermidine, verified at 99%+ purity. No extract, gluten or allergens.
Every serving delivers a full 20mg, which meets or exceeds the dosage in every major study linking spermidine to a longer life. Some protocols call for 40mg, so SPMD-99 is built to be taken once or twice a day.
AUTOPHAGY WITHOUT FASTING*
20mg 99+% PURE SPERMIDINE per serving
Other ingredients: organic acacia fiber, naturally derived plant-based hypromellose capsules, organic Nu-Flow® rice hulls
MANUFACTURED FOR Opus Longevity, Inc • San Francisco, CA 94104 • www.opus.life
Suggested use: Start with 1 capsule daily with food for the first few days, then increase to 2 capsules with food. Up to 4 capsules per day. For best results, take for a minimum of 4 months and beyond.
Consult a medical doctor before taking this or any other supplement if you are pregnant, nursing, have a medical condition or are taking any medications.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Keep this and all other supplements out of the reach of children.
SPMD-99 pairs with BROQ and NMN-99.
NMN-99 rebuilds NAD+, which your cells need for DNA repair, energy and the cleanup SPMD-99 switches on.
BROQ supports a longer, healthier life and supercharges your immune system. NMN-99 powers longevity, repairs DNA and restores energy.
Both go into your cart as separate items, on the plan shown on the button.
Add bothSubscribe & Save · $118.15/moLeading longevity scientists recommend sulforaphane, NMN and spermidine more than any other supplements.
The questions people ask.
Do I take it with food?
Yes. Take it with your last meal of the day. Start with 1 capsule for the first few days, then move to 2. You can go up to 4 capsules a day.
How do I know what's in it?
We buy each product online and have it shipped directly to an independent 3rd-party lab. Lab reports state that product was received in unopened retail packaging. Every batch is tested, and we publish the report. The batch on sale now measured 21.9 mg of spermidine per serving, against 20 mg on the label.
Why 20 mg?
Every serving delivers a full 20 mg, which meets or exceeds the dosage in every major study linking spermidine to a longer life. Some protocols call for 40 mg, so SPMD-99 is built to be taken once or twice a day.
Is it gluten-free?
Yes. SPMD-99 is pure spermidine, not wheat germ extract, so there's no wheat and no gluten, and it's free from the 9 major allergens. There are only 3 ingredients: spermidine, organic acacia fiber and organic rice hulls.
When will I notice it?
Hair is usually first. The hair study measured the change at 90 days. The deeper cleanup happens inside, so take it every day for at least 4 months. Run a panel with immune markers before you start and again at 4 months. In a recent clinical study, spermidine reversed declining immune function.
What if it's not for me?
30-days to get a FULL refund on prepaid 12-month subscriptions
It's on us, even on a one-time purchase. Just email hello@opus.life with your order number, and you get a refund.
Can I pause or cancel?
With Subscribe & Save, yes, any time, and you do it yourself. Log in to your account to pause, skip a delivery, change the date or cancel outright. You can also email hello@opus.life and we'll take care of it. The Annual Subscription is prepaid for 12 months. How subscriptions work
Can I take all three together?
Yes. They're best as a stack, and they work side by side without getting in each other's way.
Start taking out the trash.
Have your cake and eat it too. Get the benefits of fasting. Without the fasting.
30-days to get a FULL refund on prepaid 12-month subscriptions
FREE SHIPPING IN THE US