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Benefits & Science

Live longer, and feel more alive while you do.

Leading longevity scientists recommend sulforaphane, NMN and spermidine more than any other supplements.

See the published science behind them

PROVEN IN 3,000+ STUDIES

A longer life. A supercharged immune system.

Sulforaphane is a natural compound found in broccoli. It works deep inside your cells to slow aging where it starts.

A man laughing as he kneels in a vegetable garden holding freshly picked kale and broccoli.

  • Longevity

    Supports overall health, performance, and longevity.

  • Immunity

    Activates antioxidant defenses and immune cell activity.

  • Inflammation

    Calms chronic inflammation, the biggest driver of aging.

  • Heart

    Supports flexible vessels and healthy cholesterol.

  • Brain

    Protects neurons for clarity, memory, and focus.

  • Energy

    Supports mitochondria for clean, stimulant-free energy.

  • Metabolism

    Steadies blood sugar, supports insulin sensitivity.

  • Detox

    Activates the enzymes that clear the toxins you take in every day.

  • Skin and hair

    Supports your skin's own defenses against sun damage, and healthy hair.

See the science behind these

A man rinsing kale and broccoli under the tap at a kitchen sink.

Flush out microplastics and other toxins.

Sulforaphane switches on the body’s own detox pathways, the ones that clear microplastics, pollutants and other harmful substances.

A woman smiling by a bright window, running a hand through her curls.

Clearer skin. Stronger hair.

Sulforaphane lowers the internal stress that shows on your skin, supporting clearer, smoother skin and stronger hair.

When you'll notice it

Take BROQ for at least 90 days, and you can see the results in your blood test results.

Run a panel with A1C (blood sugar) and CRP (inflammation). In a clinical trial, sulforaphane lowered A1C.

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WORLD’S FIRST clinically proven NMN

Rewind aging at the source.

NAD+ is the longevity molecule. Nothing in you ages well without it. Your body makes less of it every year starting in your twenties.

A woman running toward the camera on an autumn woodland trail, laughing.

  • Longevity

    Fuels the enzymes science links to longer life.

  • DNA repair

    Powers the enzymes that fix daily DNA breaks.

  • Energy

    Powers the mitochondria that make your energy.

  • Brain

    Helps keep your brain sharp.

  • Heart

    Your heart stays powered. It never gets a night off.

  • Cellular cleanup

    Powers autophagy, your cells' own cleanup.

  • Skin

    Helps protect skin cells from the sun's damage.

See the science behind these

A woman in a navy cycling jersey smiling as she unclips her helmet beside her road bike on a quiet country lane.

You can go back to 25.

Your NAD+ peaked at 25. It has been falling ever since. In a clinical trial, NMN restored it to the age-25 peak level.

This applies on average and not to every individual.

A woman lifting a linen sun hat and smiling up at the sun in a green garden.

Repair and renew your skin.

NAD+ supports the cells that build collagen and elastin. NMN rebuilds NAD+ in a single step.

When you'll notice it

Most people feel a difference in energy within two weeks.

Run an NAD+ blood test. Taking NMN every day more than doubles your blood NAD+ levels.

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RANKED #1 of 146 compounds

The benefits of fasting, without the fasting.

Autophagy is the process by which every cell in your body takes out the trash.

A man laughing as he walks along a stone harbour waterfront at golden hour.

  • Longevity

    The strongest link to a longer life.

  • Cellular cleanup

    Triggers the cleanup fasting is famous for.

  • Hair

    Fuller, thicker hair, backed by clinical data.

  • Heart

    Helps keep your hardest-working muscle strong.

  • Skin

    Drives collagen production and strengthens the moisture barrier.

  • Brain

    Clears the protein buildup that clouds thinking and memory.

  • Immunity

    Reversed immune decline in a clinical study.

  • Microplastics

    Helps remove microplastics from the body.

See the science behind these

A woman laughing at a sunlit kitchen table over a breakfast bowl of yogurt, berries and seeds.

Fuller hair. Stronger nails. Firmer skin.

One molecule behind all of it. In a placebo-controlled study lasting 90 days, spermidine pushed significantly more follicles back into active growth.

A man pouring water from a glass carafe at a wooden table set with fruit and bread.

Clean up the microplastics.

Spermidine and sulforaphane are two of the only supplements shown to help remove microplastics from the body.

When you'll notice it

You'll usually see it in your hair first, at around 90 days.

Run a panel with immune markers. In a recent clinical study, spermidine reversed declining immune function.

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What the published research found.

Open any product to see each finding and the journal that published it.

Published in

  • Science
  • Nature Medicine
  • Cell Metabolism
  • PNAS
  • Nature Cell Biology
  • American Journal of Clinical Nutrition
  • GeroScience
  • Aging Cell

What the studies found

Longevity

A 22% lower risk of death among people who ate the most broccoli-family vegetables, compared with those who ate the least.

  1. Zhang et al., 2011. Am J Clin Nutr. (opens in a new tab)

Back to BROQ

Immunity

Less flu virus after exposure to a live flu virus, in smokers who ate broccoli sprouts for just 4 days, compared with placebo.

  1. Müller et al., 2016. PLoS One. (opens in a new tab)
  2. Riedl et al., 2009. Clin Immunol. (opens in a new tab)
  3. Noah et al., 2014. PLoS One. (opens in a new tab)
Show more studies
  1. Saito et al., 2025. J Nutr Sci. (opens in a new tab)
  2. Mazarakis et al., 2021. Nutrients. (opens in a new tab)
  3. Mazarakis et al., 2021. Int J Antimicrob Agents. (opens in a new tab)
  4. Ordonez et al., 2022. Commun Biol. (opens in a new tab)
  5. Singh et al., 2009. (opens in a new tab)
  6. Harvey et al., 2011. Sci Transl Med. (opens in a new tab)

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Inflammation

Lower blood markers of inflammation in overweight adults who ate broccoli sprouts daily for 10 weeks. The markers rose again after they stopped.

  1. López-Chillón et al., 2019. Clin Nutr. (opens in a new tab)
  2. Giron et al., 2024. Front Nutr. (opens in a new tab)
  3. Houshialsadat et al., 2022. Jundishapur J Nat Pharm Prod. (opens in a new tab)
Show more studies
  1. Heber et al., 2014. Food Funct. (opens in a new tab)
  2. Yusin et al., 2021. Nutrients. (opens in a new tab)
  3. Mazarakis et al., 2020. Clin Nutr. (opens in a new tab)
  4. Zhu et al., 2024. Redox Biol. (opens in a new tab)
  5. Pagliarani et al., 2026. Pharmacol Rep. (opens in a new tab)
  6. Bahiraii et al., 2022. Front Immunol. (opens in a new tab)
  7. Greaney et al., 2016. J Leukoc Biol. (opens in a new tab)

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Heart

LDL cholesterol down 5 to 7% in 12 weeks, in two controlled trials of a broccoli bred to make more sulforaphane.

  1. Connolly et al., 2024. BMC Med. (opens in a new tab)
  2. Armah et al., 2015. Mol Nutr Food Res. (opens in a new tab)
  3. Darand et al., 2022. Phytother Res. (opens in a new tab)
Show more studies
  1. Bahadoran et al., 2012. Diabetes Res Clin Pract. (opens in a new tab)
  2. Langston-Cox et al., 2021. Reprod Sci. (opens in a new tab)
  3. Delfan et al., 2025. Nutrients. (opens in a new tab)
  4. Mirmiran et al., 2014. J Diabetes Metab Disord. (opens in a new tab)
  5. Blekkenhorst et al., 2017. J Am Heart Assoc. (opens in a new tab)
  6. Ma et al., 2018. Clin Epidemiol. (opens in a new tab)
  7. Bose et al., 2020. Aging Cell. (opens in a new tab)

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Brain

Faster processing speed and less low mood in healthy older adults taking sulforaphane, compared with placebo.

  1. Shimizu et al., 2026. Front Nutr. (opens in a new tab)
  2. Nouchi et al., 2022. Front Aging Neurosci. (opens in a new tab)
  3. Nouchi et al., 2021. Nutrients. (opens in a new tab)
Show more studies
  1. Sedlak et al., 2018. Mol Neuropsychiatry. (opens in a new tab)
  2. Ou et al., 2024. J Autism Dev Disord. (opens in a new tab)
  3. Hei et al., 2022. Schizophr Bull Open. (opens in a new tab)
  4. Singh et al., 2014. PNAS. (opens in a new tab)
  5. Shimizu et al., 2022. Int J Mol Sci. (opens in a new tab)
  6. Lee et al., 2018. Mol Nutr Food Res. (opens in a new tab)
  7. Bessetti & Litwa, 2025. Front Cell Neurosci. (opens in a new tab)

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Energy

Better results from intense exercise training, and less of the stress it puts on the body, in people taking broccoli sprouts.

  1. Flockhart et al., 2023. Redox Biol. (opens in a new tab)
  2. Sato et al., 2021. Nutrition. (opens in a new tab)
  3. Rodriguez et al., 2026. GeroScience. (opens in a new tab)
Show more studies
  1. Champsi & Hood, 2025. Am J Physiol Cell Physiol. (opens in a new tab)
  2. Ruhee & Suzuki, 2020. Antioxidants. (opens in a new tab)
  3. Shimizu et al., 2022. Int J Mol Sci. (opens in a new tab)
  4. Oh et al., 2017. Sci Rep. (opens in a new tab)
  5. Plafker et al., 2025. Front Nutr. (opens in a new tab)
  6. Bose et al., 2020. Aging Cell. (opens in a new tab)
  7. Malaguti et al., 2009. J Appl Physiol. (opens in a new tab)

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Metabolism

Lower fasting blood sugar and A1C after 12 weeks of sulforaphane, compared with placebo, in obese adults with poorly controlled type 2 diabetes.

  1. Axelsson et al., 2017. Sci Transl Med. (opens in a new tab)
  2. Dwibedi et al., 2025. Nat Microbiol. (opens in a new tab)
  3. Connolly et al., 2025. Diabetes Obes Metab. (opens in a new tab)
Show more studies
  1. Darand et al., 2022. Phytother Res. (opens in a new tab)
  2. Bahadoran et al., 2012. Int J Food Sci Nutr. (opens in a new tab)
  3. Delfan et al., 2025. Nutrients. (opens in a new tab)
  4. Tian et al., 2024. Food Funct. (opens in a new tab)
  5. Bernuzzi et al., 2023. Redox Biol. (opens in a new tab)
  6. Kikuchi et al., 2015. World J Gastroenterol. (opens in a new tab)
  7. Nagata et al., 2017. Diabetes. (opens in a new tab)

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Detox

People on a daily broccoli sprout drink flushed out 61% more of a toxic car-exhaust pollutant in 12 weeks, compared with placebo.

  1. Egner et al., 2014. (opens in a new tab)

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Skin and hair

37.7% less redness from UV light, on average, when sulforaphane-rich broccoli sprout extract was applied to people's skin.

  1. Talalay et al., 2007. Proc Natl Acad Sci U S A. (opens in a new tab)

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What the studies found

Longevity

Biological age, measured from a blood panel, held steady over 60 days on NMN in adults aged 40 to 65, while it rose on placebo.

  1. Yi et al., 2023. GeroScience. (opens in a new tab)
  2. Mills et al., 2016. Cell Metab. (opens in a new tab)
  3. Song et al., 2023. Adv Nutr. (opens in a new tab)
Show more studies
  1. Niu et al., 2021. Front Nutr. (opens in a new tab)
  2. Nadeeshani et al., 2022. J Adv Res. (opens in a new tab)
  3. Zhou et al., 2025. J Nutr. (opens in a new tab)
  4. Li et al., 2017. Science. (opens in a new tab)
  5. Camacho-Pereira et al., 2016. Cell Metab. (opens in a new tab)
  6. Covarrubias et al., 2020. Nat Metab. (opens in a new tab)
  7. Massudi et al., 2012. PLoS One. (opens in a new tab)

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DNA repair

When DNA repair was failing, restoring NAD+ protected brain cells and improved balance.

  1. Li et al., 2017. Science. (opens in a new tab)
  2. Fang et al., 2016. Cell Metab. (opens in a new tab)
  3. Yi et al., 2023. GeroScience. (opens in a new tab)
Show more studies
  1. Yang et al., 2021. Aging Cell. (opens in a new tab)
  2. Song et al., 2023. Adv Nutr. (opens in a new tab)
  3. Amano et al., 2019. Cell Metab. (opens in a new tab)
  4. Nadeeshani et al., 2022. J Adv Res. (opens in a new tab)
  5. Fang et al., 2014. Cell. (opens in a new tab)
  6. Scheibye-Knudsen et al., 2014. Cell Metab. (opens in a new tab)
  7. Fang, 2017. Autophagy. (opens in a new tab)

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Energy

Faster walking speed and a stronger grip in older men after 12 weeks of NMN, compared with placebo.

  1. Igarashi et al., 2022. npj Aging. (opens in a new tab)
  2. Yoshino et al., 2021. Science. (opens in a new tab)
  3. Morifuji et al., 2024. GeroScience. (opens in a new tab)
Show more studies
  1. Yi et al., 2023. GeroScience. (opens in a new tab)
  2. Wang et al., 2025. Curr Pharm Biotechnol. (opens in a new tab)
  3. Liao et al., 2021. J Int Soc Sports Nutr. (opens in a new tab)
  4. Kim et al., 2022. Nutrients. (opens in a new tab)
  5. Mills et al., 2016. Cell Metab. (opens in a new tab)
  6. Zhou et al., 2025. J Nutr. (opens in a new tab)
  7. Frederick et al., 2016. Cell Metab. (opens in a new tab)

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Brain

Two weeks of NMN restored blood flow in the brain and improved memory.

  1. Zhu et al., 2015. PNAS. (opens in a new tab)
  2. Tarantini et al., 2019. Redox Biol. (opens in a new tab)
  3. Yi et al., 2023. GeroScience. (opens in a new tab)
Show more studies
  1. Xiong et al., 2024. Cell Death Dis. (opens in a new tab)
  2. Kiss et al., 2020. GeroScience. (opens in a new tab)
  3. Yoo et al., 2021. (opens in a new tab)
  4. Zang et al., 2026. Metabolites. (opens in a new tab)
  5. Xu et al., 2026. Biochem Biophys Res Commun. (opens in a new tab)
  6. Cissé et al., 2026. iScience. (opens in a new tab)
  7. Yao et al., 2017. Neurosci Lett. (opens in a new tab)

Back to NMN-99

Heart

A lower bottom blood pressure number, by about 2 points, pooled across 10 controlled trials of NMN.

  1. Zhang et al., 2026. Nutrients. (opens in a new tab)
  2. Yi et al., 2023. GeroScience. (opens in a new tab)
  3. Katayoshi et al., 2023. Sci Rep. (opens in a new tab)
Show more studies
  1. de Picciotto et al., 2016. Aging Cell. (opens in a new tab)
  2. Wang et al., 2024. Circ Res. (opens in a new tab)
  3. Das et al., 2018. Cell. (opens in a new tab)
  4. Mateuszuk et al., 2020. Biochem Pharmacol. (opens in a new tab)
  5. Qiu et al., 2023. Signal Transduct Target Ther. (opens in a new tab)
  6. Liang et al., 2025. Pharmaceuticals. (opens in a new tab)
  7. Huang et al., 2026. Mol Biol Rep. (opens in a new tab)

Back to NMN-99

Cellular cleanup

Restoring NAD+ restarted the cells' cleanup of worn-out parts.

  1. Cui et al., 2026. Autophagy. (opens in a new tab)
  2. Yi et al., 2023. GeroScience. (opens in a new tab)
  3. Fang et al., 2016. Cell Metab. (opens in a new tab)
Show more studies
  1. Yang et al., 2021. Aging Cell. (opens in a new tab)
  2. Wang et al., 2022. Int J Mol Sci. (opens in a new tab)
  3. Miao et al., 2020. Cell Rep. (opens in a new tab)
  4. Li et al., 2025. J Transl Med. (opens in a new tab)
  5. Zhou et al., 2025. J Nutr. (opens in a new tab)
  6. Fang et al., 2014. Cell. (opens in a new tab)
  7. Fang, 2017. Autophagy. (opens in a new tab)

Back to NMN-99

Skin

NMN protected skin cells from the sun's damage.

  1. Zhang et al., 2025. Photochem Photobiol Sci. (opens in a new tab)
  2. Kim et al., 2025. Antioxidants. (opens in a new tab)
  3. Kang et al., 2025. Biomedicines. (opens in a new tab)
Show more studies
  1. Betsuno et al., 2025. J Cosmet Dermatol. (opens in a new tab)
  2. Wong et al., 2022. Mol Metab. (opens in a new tab)
  3. Seki et al., 2026. JCI Insight. (opens in a new tab)
  4. Zhou et al., 2021. J Inflamm Res. (opens in a new tab)
  5. Feng et al., 2022. Biochim Biophys Acta Mol Basis Dis. (opens in a new tab)
  6. Kang et al., 2024. Cells. (opens in a new tab)
  7. Song et al., 2023. Adv Nutr. (opens in a new tab)

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What the studies found

Longevity

Over 20 years, people with the most spermidine in their diet, versus the least, had the death risk of someone nearly 6 years younger.

  1. Kiechl et al., 2018. Am J Clin Nutr. (opens in a new tab)
  2. Han et al., 2024. Nutrients. (opens in a new tab)
  3. Wu et al., 2022. Front Public Health. (opens in a new tab)
Show more studies
  1. Nagata et al., 2024. Br J Nutr. (opens in a new tab)
  2. Ma et al., 2025. J Nutr Health Aging. (opens in a new tab)
  3. Hofer et al., 2024. Nat Cell Biol. (opens in a new tab)
  4. Eisenberg et al., 2016. Nat Med. (opens in a new tab)
  5. Hofer et al., 2022. Nat Aging. (opens in a new tab)
  6. Madeo et al., 2018. Science. (opens in a new tab)
  7. Eisenberg et al., 2009. Nat Cell Biol. (opens in a new tab)

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Cellular cleanup

The cleanup switched on inside the immune cells of older adults taking a daily spermidine supplement for 13 weeks, compared with placebo.

  1. Hofer et al., 2024. Nat Cell Biol. (opens in a new tab)
  2. Alsaleh et al., 2026. Aging Cell. (opens in a new tab)
  3. Alsaleh et al., 2020. eLife. (opens in a new tab)
Show more studies
  1. Hofer et al., 2022. Nat Aging. (opens in a new tab)
  2. Eisenberg et al., 2009. Nat Cell Biol. (opens in a new tab)
  3. Pietrocola et al., 2015. Cell Death Differ. (opens in a new tab)
  4. Zhang et al., 2019. Mol Cell. (opens in a new tab)
  5. Shi et al., 2023. Liver Int. (opens in a new tab)
  6. Sacitharan et al., 2018. Exp Mol Med. (opens in a new tab)
  7. Eisenberg et al., 2016. Nat Med. (opens in a new tab)

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Hair

About 37 of every 100 hairs in active growth after 90 days on spermidine, against about 20 on placebo.

  1. Rinaldi et al., 2017. Dermatol Pract Concept. (opens in a new tab)
  2. Ramot et al., 2011. PLoS One. (opens in a new tab)
  3. Marzani et al., 2018. G Ital Dermatol Venereol. (opens in a new tab)
Show more studies
  1. Allmeroth et al., 2021. J Cell Sci. (opens in a new tab)
  2. Ramot et al., 2015. Arch Dermatol Res. (opens in a new tab)
  3. Ramot et al., 2010. Exp Dermatol. (opens in a new tab)
  4. Fashe et al., 2010. Amino Acids. (opens in a new tab)
  5. Pietilä et al., 2001. J Invest Dermatol. (opens in a new tab)
  6. Soler et al., 1996. J Invest Dermatol. (opens in a new tab)
  7. Panteleyev et al., 2000. Exp Dermatol. (opens in a new tab)

Back to SPMD-99

Heart

About a third lower risk of dying of heart disease for the people eating the most spermidine, in a study of nearly 24,000 Americans.

  1. Kiechl et al., 2018. Am J Clin Nutr. (opens in a new tab)
  2. Han et al., 2024. Nutrients. (opens in a new tab)
  3. Eisenberg et al., 2016. Nat Med. (opens in a new tab)
Show more studies
  1. Wu et al., 2022. Front Public Health. (opens in a new tab)
  2. López-González et al., 2026. Eur J Nutr. (opens in a new tab)
  3. Matsumoto et al., 2019. Nutrients. (opens in a new tab)
  4. Wang et al., 2025. Hereditas. (opens in a new tab)
  5. Song et al., 2025. JACC Basic Transl Sci. (opens in a new tab)
  6. Liu et al., 2021. Aging Cell. (opens in a new tab)
  7. LaRocca et al., 2013. Mech Ageing Dev. (opens in a new tab)

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Skin

Firmer, better-hydrated skin when a spermidine-producing extract was applied to people's skin.

  1. Kim et al., 2021. Commun Biol. (opens in a new tab)
  2. Ito et al., 2021. Cell Commun Signal. (opens in a new tab)
  3. Wu et al., 2024. Adv Sci. (opens in a new tab)
Show more studies
  1. Anglin et al., 2025. Physiologia. (opens in a new tab)
  2. Rahim et al., 2021. J Invest Dermatol. (opens in a new tab)
  3. Lim et al., 2018. J Invest Dermatol. (opens in a new tab)
  4. Brito et al., 2022. Sci Rep. (opens in a new tab)
  5. Yu et al., 2026. Bioact Mater. (opens in a new tab)
  6. Ghisalberti et al., 2013. World J Biol Chem. (opens in a new tab)
  7. Ramot et al., 2011. PLoS One. (opens in a new tab)

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Brain

About a third lower risk of dementia over 12 years among 77,000 older adults who ate the most spermidine.

  1. Wirth et al., 2018. Cortex. (opens in a new tab)
  2. Schroeder et al., 2021. Cell Rep. (opens in a new tab)
  3. Qian et al., 2024. Nutrients. (opens in a new tab)
Show more studies
  1. Schwarz et al., 2022. JAMA Netw Open. (opens in a new tab)
  2. Pekar et al., 2021. Wien Klin Wochenschr. (opens in a new tab)
  3. Freitag et al., 2022. J Neuroinflammation. (opens in a new tab)
  4. Liang et al., 2021. Cell Rep. (opens in a new tab)
  5. Wu et al., 2026. Behav Brain Res. (opens in a new tab)
  6. Fairley et al., 2023. Int J Mol Sci. (opens in a new tab)
  7. Pandolfi et al., 2026. Mol Biol Rep. (opens in a new tab)

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Immunity

A stronger immune response to a vaccine in older adults taking spermidine for 13 weeks, most of all in those who had responded weakly.

  1. Alsaleh et al., 2026. Aging Cell. (opens in a new tab)
  2. Alsaleh et al., 2020. eLife. (opens in a new tab)
  3. Zhang et al., 2019. Mol Cell. (opens in a new tab)
Show more studies
  1. Chamoto et al., 2024. Trends Cell Biol. (opens in a new tab)
  2. Al-Habsi et al., 2022. Science. (opens in a new tab)
  3. Puleston et al., 2019. Cell Metab. (opens in a new tab)
  4. Puleston et al., 2021. Cell. (opens in a new tab)
  5. Liu et al., 2025. Phytomedicine. (opens in a new tab)
  6. Pham et al., 2026. Arthritis Rheumatol. (opens in a new tab)
  7. Niechcial et al., 2023. J Crohns Colitis. (opens in a new tab)

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Every study we cite

BROQ

  1. Armah CN, Derdemezis C, Traka MH, et al. (2015). Mol Nutr Food Res. (opens in a new tab)
  2. Axelsson AS, Tubbs E, Mecham B, et al. (2017). Sci Transl Med. (opens in a new tab)
  3. Bahadoran, Z., Mirmiran, P., & Azizi, F. (2020). Journal of Functional Foods.
  4. Connolly EL, Liu AH, Radavelli-Bagatini S, et al. (2024). BMC Med. (opens in a new tab)
  5. Connolly EL, Liu AH, Woodman RJ, et al. (2025). Diabetes Obes Metab. (opens in a new tab)
  6. Darand M, Alizadeh S, Mansourian M (2022). Phytother Res. (opens in a new tab)
  7. Dwibedi C, Axelsson AS, Abrahamsson B, et al. (2025). Nat Microbiol. (opens in a new tab)
  8. Egner, P. A., Chen, J. G., Wang, J. B., Wu, Y., Sun, Y., Lu, W., ... & Kensler, T. W. (2011).
  9. Egner PA, Chen JG, Zarth AT, et al. (2014). (opens in a new tab)
  10. Flockhart M, Nilsson LC, Tillqvist EN, et al. (2023). Redox Biol. (opens in a new tab)
  11. Giron J, Smiarowski L, Katz J (2024). Front Nutr. (opens in a new tab)
  12. Greaney AJ, Maier NK, Leppla SH, et al. (2016). J Leukoc Biol. (opens in a new tab)
  13. Houshialsadat Z, Mirmiran P, Zare-Javid A, Bahadoran Z, Houghton C (2022). Jundishapur J Nat Pharm Prod. (opens in a new tab)
  14. Kim, J., Kim, J., & Kang, H. (2013). Molecular Nutrition & Food Research.
  15. López-Chillón MT, Carazo-Díaz C, Prieto-Merino D, et al. (2019). Clin Nutr. (opens in a new tab)
  16. Müller L, Meyer M, Bauer RN, et al. (2016). PLoS One. (opens in a new tab)
  17. Nagata N, Xu L, Kohno S, et al. (2017). Diabetes. (opens in a new tab)
  18. Noah TL, Zhang H, Zhou H, et al. (2014). PLoS One. (opens in a new tab)
  19. Nouchi R, Hu Q, Saito T, et al. (2021). Nutrients. (opens in a new tab)
  20. Nouchi R, Hu Q, Saito T, et al. (2022). Front Aging Neurosci. (opens in a new tab)
  21. Riedl MA, Saxon A, Diaz-Sanchez D (2009). Clin Immunol. (opens in a new tab)
  22. Rodriguez DJ, Ostrom EL, Chassman C, et al. (2026). Geroscience. (opens in a new tab)
  23. Sato K, Kihara H, Kumazawa Y, et al. (2021). Nutrition. (opens in a new tab)
  24. Shimizu S, Kasai S, Suzuki C, et al. (2026). Front Nutr. (opens in a new tab)
  25. Talalay et al. (2007). Proc Natl Acad Sci U S A. (opens in a new tab)
  26. Zhang et al. (2011). Am J Clin Nutr. (opens in a new tab)

NMN-99

  1. Bhasin et al. (2023). J Gerontol A Biol Sci Med Sci. (opens in a new tab)
  2. Christen S, et al. (2026). Nature Metabolism.
  3. Fang EF, Kassahun H, Croteau DL, et al. (2016). Cell Metab. (opens in a new tab)
  4. Huang H (2022). Frontiers in Aging.
  5. Igarashi M, et al. (2022). npj Aging. (opens in a new tab)
  6. Kang S, Park J, Cho E, et al. (2025). Biomedicines. (opens in a new tab)
  7. Katayoshi T, Uehata S, Nakashima N, et al. (2023). Sci Rep. (opens in a new tab)
  8. Kim SJ, Lee S, Choi YJ, et al. (2025). Antioxidants (Basel). (opens in a new tab)
  9. Li J, Bonkowski MS, Moniot S, et al. (2017). Science. (opens in a new tab)
  10. Liao B, Zhao Y, Wang D, et al. (2021). J Int Soc Sports Nutr. (opens in a new tab)
  11. Mills KF, Yoshida S, Stein LR, et al. (2016). Cell Metab. (opens in a new tab)
  12. Morifuji M, Higashi S, Ebihara S, et al. (2024). Geroscience. (opens in a new tab)
  13. Song Q, Zhou X, Xu K, Liu S, Zhu X, Yang J (2023). Adv Nutr. (opens in a new tab)
  14. Tarantini S, Valcarcel-Ares MN, Toth P, et al. (2019). Redox Biol. (opens in a new tab)
  15. Yi L, et al. (2023). GeroScience. (opens in a new tab)
  16. Yoshino M, Yoshino J, Kayser BD, et al. (2021). Science. (opens in a new tab)
  17. Zhang Y, Ai C, Huang F, et al. (2025). Photochem Photobiol Sci. (opens in a new tab)
  18. Zhang M, Chen Y, Jiang N, et al. (2026). Nutrients. (opens in a new tab)
  19. Zhu XH, Lu M, Lee BY, et al. (2015). Proc Natl Acad Sci U S A. (opens in a new tab)

SPMD-99

  1. Alsaleh G, Panse I, Swadling L, et al. (2020). eLife. (opens in a new tab)
  2. Alsaleh G, Ali M, Kayvanjoo AH, et al. (2026). Aging Cell. (opens in a new tab)
  3. Eisenberg T, Abdellatif M, Schroeder S, et al. (2016). Nat Med. (opens in a new tab)
  4. Han S, Qian M, Zhang N, et al. (2024). Nutrients. (opens in a new tab)
  5. Hofer SJ, Daskalaki I, Bergmann M, et al. (2024). Nat Cell Biol. (opens in a new tab)
  6. Kiechl S, Pechlaner R, Willeit P, et al. (2018). Am J Clin Nutr. (opens in a new tab)
  7. Marzani B, Pinto D, Sorbellini E, et al. (2018). G Ital Dermatol Venereol. (opens in a new tab)
  8. Qian M, Zhang N, Zhang R, et al. (2024). Nutrients. (opens in a new tab)
  9. Ramot Y, Tiede S, Bíró T, et al. (2011). PLoS One. (opens in a new tab)
  10. Rinaldi F, Marzani B, Pinto D, et al. (2017). Dermatol Pract Concept. (opens in a new tab)
  11. Schroeder S, Hofer SJ, Zimmermann A, et al. (2021). Cell Rep. (opens in a new tab)
  12. Wirth M, Benson G, Schwarz C, et al. (2018). Cortex. (opens in a new tab)
  13. Wu H, Wang J, Jiang H, et al. (2022). Front Public Health. (opens in a new tab)
  14. Zhang H, Alsaleh G, Feltham J, et al. (2019). Mol Cell. (opens in a new tab)

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