Leading longevity scientists recommend sulforaphane, NMN and spermidine more than any other supplements.
Spermidine: linked to nearly 6 years of longer life
NMN: put your NAD+ back where it was at 25
Sulforaphane: less inflammation, stronger immunity, more energy
All three products
BROQ, NMN-99 and SPMD-99Subscribe and saveRegular price $183.00$145.55/mo20% offIncludes an ADDITIONAL $10 off per month for all threeFree shipping on subscriptions anywhere in the US.
180-day money-back guarantee. No need to send anything back. Annual subscriptions are fully refundable for 30 days after your first delivery.
Flip them overEvery ingredient and every milligram on the back of each package. Zoom in →
Flip them overEvery ingredient and every milligram on the back of each package. Zoom in →
✓Lab tested against the top-selling competitors✓180-Day Money Back Guarantee✓ Free shipping on subscriptions anywhere in the US.
Annual subscriptions are fully refundable for 30 days after your first delivery.
Your NAD+ peaked at 25. It has been falling ever since. In a clinical trial, NMN restored it to the age-25 peak level.You can go back to 25.
(This applies on average and not to every individual.) Igarashi M, et al. npj Aging. 2022;8(1):5. Yi L, et al. GeroScience. 2023;45(1):29 to 43.
7 proven benefits of NAD+.
Taking NMN every day more than doubles your blood NAD+ levels. Here is what that means for you:
Longevity. NAD+ fuels sirtuins, the enzymes science links to longer life. When NAD+ drops, sirtuins go quiet.
DNA repair. NAD+ powers the enzymes that repair tens of thousands of DNA breaks every single day.
Cellular energy. NAD+ is how your mitochondria make energy and recycle themselves when they wear out.
Brain. NAD+ fuels your neurons and the repair pathways that keep them working.
Heart. Your heart beats 100,000 times a day and never gets a night off. NAD+ is what keeps it powered.
Cellular renewal. NAD+ powers autophagy, the system your cells use to clear debris and rebuild.
Skin. NAD+ supports the cells that produce collagen and elastin.
SPMD-99Cellular renewal
Linked to nearly6years of longer life
Kiechl et al., 2018. Higher spermidine intake is linked to lower mortality: a prospective population-based study. American Journal of Clinical Nutrition.
7 proven benefits of spermidine.
Longevity. Scientists tracked 146 compounds over 20 years. Spermidine ranked first for its link to a longer life.
Cellular renewal. Spermidine triggers autophagy, the cellular renewal fasting is famous for. Without skipping a meal.
Hair. Fuller, thicker hair. In a placebo-controlled study, spermidine drove more follicles into active growth.
Heart. Spermidine helps keep your hardest-working muscle running strong.
Skin. Spermidine drives collagen production and strengthens the moisture barrier that keeps skin firm.
Brain. Spermidine crosses the blood-brain barrier and clears the toxic protein buildup that clouds thinking.
Immunity. In a clinical trial, spermidine improved immune function.
The stack
They're best as a stack.
Together, they help you live longer and feel stronger, sharper, and more alive with every passing year.
How BROQ, NMN-99 and SPMD-99 work together inside your cells.
BROQSulforaphane
NMN-99NMN
SPMD-99Spermidine
Role in the stack
BROQCellular defense
NMN-99Cellular energy
SPMD-99Cellular renewal
Primary mechanism
BROQActivates Nrf2, your master switch for antioxidant and detox genes
NMN-99Rebuilds NAD+, the coenzyme your cells need for DNA repair and energy
SPMD-99Triggers autophagy, the cleanup process your cells run during fasting
What it does inside a cell
BROQSwitches on the cell’s defenses
NMN-99Restores the cell’s energy supply
SPMD-99Clears out the cell’s waste
Key pathway
BROQNrf2/KEAP1/ARE
NMN-99NAD+/SIRT1/PARP
SPMD-99Autophagy/mTOR/EP300
BROQRole in the stackCellular defensePrimary mechanismActivates Nrf2, your master switch for antioxidant and detox genesWhat it does inside a cellSwitches on the cell’s defensesKey pathwayNrf2/KEAP1/ARE
NMN-99Role in the stackCellular energyPrimary mechanismRebuilds NAD+, the coenzyme your cells need for DNA repair and energyWhat it does inside a cellRestores the cell’s energy supplyKey pathwayNAD+/SIRT1/PARP
SPMD-99Role in the stackCellular renewalPrimary mechanismTriggers autophagy, the cleanup process your cells run during fastingWhat it does inside a cellClears out the cell’s wasteKey pathwayAutophagy/mTOR/EP300
BROQ protects your cells. NMN-99 powers them. SPMD-99 takes out the trash. Your cells need all three.
Independent lab tests
We are the only supplement brand to give you proof.
An independent 3rd-party lab tested each product. Lab reports state that product was received in unopened retail packaging.
Each one delivers the daily dosages used in the studies that showed its benefits.¹
¹ With BROQ, you may need to take more than one serving per day to reach these levels.
BROQ
High potency sulforaphane
25 mg per serving
More than double the sulforaphane of 18 of the top 20 competitors.
Per serving, as each brand’s label defines a serving.
For delayed-release products, BROQ among them, the result is the test in water (pH 7.3), because they open past the stomach. For immediate-release products, it’s the average of two tests: one in water (pH 7.3) and one in acid (pH 1.5, like the stomach).
The chart uses BROQ’s result from the same tests as the other brands. The batch on sale now tested even higher, at 34.1 mg.
NMN-99
High potency NMN
Tested 1,139.6 mgLabel says 1,000 mg
More than double the NMN of 4 out of the 5 top-selling competitors.
Per serving, as each brand’s label defines a serving.
SEE THE RESULTS IN YOUR BLOODWORK OR DON'T PAY
Take all three for 4 months, with a blood test at the beginning and blood test at the end. If you don't see an improvement in biomarkers, tell us and you'll get a full refund.
Full refund within 180 days for any reason.Annual subscriptions are fully refundable for 30 days after your first delivery.
All three fit into one daily routine.
In the morning
BROQ
On an empty stomach or 30 minutes after a mealWhen you'll notice itTake BROQ for at least 90 days, and you can see the results in your blood test results.What blood work can showRun a panel with A1C (blood sugar) and CRP (inflammation). In a clinical trial, sulforaphane lowered A1C.
In the morning
NMN-99
With or without foodWhen you'll notice itMost people feel a difference in energy within two weeks.What blood work can showRun an NAD+ blood test. Taking NMN every day more than doubles your blood NAD+ levels.
With your last meal
SPMD-99
With food. Start with 1 capsule, then 2 after a few days.When you'll notice itYou'll usually see it in your hair first, at around 90 days.What blood work can showRun a panel with immune markers. In a recent clinical study, spermidine reversed declining immune function.
Trust the label
Made in California, the right way.
BROQ, NMN-99 and SPMD-99 are each produced in California, in a highly advanced FDA-registered facility that has GMP certification from NSF, UL, and the Natural Products Association, as well as organic and Non-GMO certifications. Independently lab tested for purity and potency.
FDA-registered facility
GMP certified
Certificate of analysis on every lot
Made in USA
What our customers say
★★★★★
The openness about testing won me over
I am cautious about supplement marketing. What stood out to me was the emphasis on ingredient amounts, outside lab work, and explaining the founders’ choices. That gave me enough confidence to try the three-product combination.
Philip R.
★★★★★
I wanted actual measurements
The comparison chart caught my eye because I had been buying a broccoli supplement based on the front label alone. I read the test method and reports before ordering BROQ. I appreciate being able to judge the delivered amount instead of a big-sounding extract number.
Adrian F.BROQ
★★★★★
I checked the ingredient supplier first
I compare supplement labels pretty carefully. Seeing the named NMN ingredient and the testing information helped me choose this one. The capsules fit into my morning routine without any fuss.
Jocelyn T.NMN‑99
★★★★★
I preferred a clearly defined ingredient
I used to buy a wheat-germ supplement without being sure how much spermidine I was actually getting. SPMD-99 gives me a specific amount to compare. For someone who reads labels closely, that matters more than a long ingredient story.
Priya S.SPMD‑99
★★★★☆
Simpler than my old collection
I replaced several scattered purchases with the three-product stack. The daily capsule count is manageable for me, and I like being able to find the ingredient details in one place. I will assess the results over the next few months.
Marissa K.
★★★★★
I keep returning to this one
I have used BROQ on and off for years. Whenever I simplify my cabinet, it is one of the few things I bring back. I value the consistent testing information and the fact that I can read what is actually in each serving.
Yes. They’re best as a stack, and they work side by side without getting in each other’s way.
Why these over cheaper versions?
Because in this category, cheap usually means you are not getting the molecule you paid for.
BROQ. 25 mg of sulforaphane per serving. More than double the sulforaphane of 18 of the top 20 competitors. BROQ’s capsule opens past the stomach, so the conversion happens where your body can absorb the result.
NMN-99. In a test of 22 NMN supplements, 14 of them contained less than 1% of the NMN on the label. (Niagen Bioscience, 2021.) NMN-99 uses only Uthever®, the world’s first patented NMN, verified at 99+% pure beta-NMN, with a manufacturer’s certificate of analysis for every lot.
SPMD-99. Most spermidine supplements use wheat germ extract: a big capsule of plant material with roughly 1% actual spermidine, and the amount varies. SPMD-99 contains the pure molecule, verified lot by lot.
We built all three to be the best you can buy, not the cheapest.
How soon will I notice anything?
Most people feel a difference in energy within the first two weeks. NAD+ powers every cell in your body, and energy is usually the first change people notice.
In a placebo-controlled study lasting 90 days, spermidine pushed significantly more follicles back into active growth. Hair is usually where people see it first.
Sulforaphane works best taken every day, and the effect builds. The rest of the work happens inside and you will not feel most of it.
If you want to see it rather than feel it, run an ordinary blood panel before you start and another one 4 months in.
What if it’s not for me?
Full refund within 180 days for any reason. No need to send anything back. Email hello@opus.life with your order number, and you get a refund.
Annual subscriptions are fully refundable for 30 days after your first delivery.
When should I take them?
Take BROQ and NMN-99 in the morning, when your body is primed for energy and defense. Take SPMD-99 with your last meal, when your cells naturally shift into repair mode. That said, any time of day works. Consistency matters most.
What is in the capsules?
BROQ. Three things. Broccoli seed extract at 92%, horseradish at 5% for the myrosinase enzyme that converts it, and organic rice hulls at 3% to keep the powder dry.
NMN-99. The capsules are plant based and hold three ingredients: NMN, organic acacia fiber and organic rice hulls.
SPMD-99. Three ingredients. Plant-based capsules holding spermidine, organic acacia fiber and organic rice hulls. No wheat germ. No gluten. Free from the 9 major allergens.
That is the whole list.
How do the plans work?
Each product is its own line in your cart and its own subscription. Subscribe & Save ships and bills it every month until you change or cancel it online. The Annual Subscription is prepaid for 12 months. One-time is one order.
Can I pause or cancel?
Yes, any time, and you do it yourself. Each product is its own subscription. Skip, pause or cancel any one online.
Subscribe & Save. You can skip a delivery, change the date, change the frequency or cancel outright in your account, and none of it needs an email or a phone call.
Annual Subscription. Pause anytime. Annual subscriptions are fully refundable for 30 days after your first delivery.
Is shipping free?
Yes. Free shipping in the US on all subscriptions and on orders over $99.
One decision
Start the 3 supplements longevity scientists recommend most.
All three products: $145.55/mo with Subscribe & Save. $4.85 a day.
