Can aging be reversed? These 7 supplements give you the best shot.
Based on most recent scientific research, as of October, 2026
By Mike X Franzini, co-founder and CEO, Opus Longevity
4.898% recommend
1,643 reviews from verified customers
Here they are, ranked from 1 to 7, based on how compelling the scientific support is.
- 1. Sulforaphane: BROQ
- 2. Spermidine: SPMD-99
- 3. NMN: NMN-99
- 4. Urolithin A: Mitopure
- 5. Omega-3: Momentous
- 6. Fisetin: Renue By Science
- 7. Vitamin D3 and K2: Thorne
Leading longevity scientists recommend sulforaphane, NMN and spermidine more than any other supplements.
Cellular defenseBROQMore than double the sulforaphane of 18 of the top 20 competitors.
Cellular renewalSPMD-99Double the spermidine of 4 out of the 5 top-selling competitors.
Cellular energyNMN-99More than double the NMN of 4 out of the 5 top-selling competitors.
1. Sulforaphane: BROQ
Cellular defense
Less inflammation, stronger immunity, more energy
It is the single most studied molecule in longevity, and BROQ is built to deliver it.
Sulforaphane is a natural compound found in broccoli. In thousands of studies it works deep inside your cells to slow aging where it starts.
Switches on the cell’s defensesActivates Nrf2, your master switch for antioxidant and detox genes
6 ways BROQ works for you.
The sulforaphane in BROQ has been shown in clinical studies to support six key areas of health.
- Inflammation.Calms chronic inflammation, the biggest driver of aging.
- Immunity.Activates antioxidant defenses and NK cell activity.
- Heart.Supports flexible vessels and healthy cholesterol.
- Brain.Protects neurons for clarity, memory, and focus.
- Energy.Supports mitochondria for clean, stimulant-free energy.
- Metabolism.Steadies blood sugar, supports insulin sensitivity.
Sulforaphane also activates your body’s own detoxification pathways, the enzymes that process and clear the environmental toxins you take in every day.
We are the only supplement brand to give you proof.
More than double the sulforaphane of 18 of the top 20 competitors.
BROQ’s capsule opens past the stomach, so the conversion happens where your body can absorb the result.
An independent 3rd-party lab tested each product. Lab reports state that product was received in unopened retail packaging.
You can see the actual original lab report for all these products, right here.
Sulforaphane per serving.
Per serving, as each brand’s label defines a serving.
For delayed-release products, BROQ among them, the result is the test in water (pH 7.3), because they open past the stomach. For immediate-release products, it’s the average of two tests: one in water (pH 7.3) and one in acid (pH 1.5, like the stomach).
The chart uses BROQ’s result from the same tests as the other brands. The batch on sale now tested even higher, at 34.1 mg.
Take BROQ for at least 90 days, and you can see the results in your blood test results.
Run a panel with A1C (blood sugar) and CRP (inflammation). In a clinical trial, sulforaphane lowered A1C.
BROQCellular defenseSupports a longer, healthier life and supercharges your immune system
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Save an ADDITIONAL $10 per month when you subscribe to all three.
2. Spermidine: SPMD-99
Cellular renewal
Linked to nearly 6 years of longer life
In a 20-year study comparing 146 compounds, spermidine had the strongest link to a longer life of any nutrient measured. Nearly six more years.
Kiechl et al., 2018. Higher spermidine intake is linked to lower mortality: a prospective population-based study. American Journal of Clinical Nutrition.
Your cells think you’re fasting.
Get the benefits of fasting. Without the fasting.
Autophagy is the process by which every cell in your body takes out the trash. Fasting is the famous way to trigger it.
But autophagy slows with age, and the junk it once cleared piles up.
Worn-out parts, piling up. Autophagy clears them, and spermidine is what switches autophagy back on.
Nobel Prize, 2016. The prize was awarded for discovering how autophagy works.
7 proven benefits of spermidine.
- Longevity.Scientists tracked 146 compounds over 20 years. Spermidine ranked first for its link to a longer life.
- Cellular renewal.Spermidine triggers autophagy, the cellular renewal fasting is famous for. Without skipping a meal.
- Hair.Fuller, thicker hair. In a placebo-controlled study, spermidine drove more follicles into active growth.
- Heart.Spermidine helps keep your hardest-working muscle running strong.
- Skin.Spermidine drives collagen production and strengthens the moisture barrier that keeps skin firm.
- Brain.Spermidine crosses the blood-brain barrier and clears the toxic protein buildup that clouds thinking.
- Immunity.In a clinical trial, spermidine improved immune function.
Fuller hair. Stronger nails. Firmer skin. One molecule behind all of it.
The highest dose in any leading brand.
Double the spermidine of 4 out of the 5 top-selling competitors.
You can see the actual original lab report for all these products, right here.
Spermidine per serving.
Per serving, as each brand’s label defines a serving.
Most spermidine supplements use wheat germ extract: a big capsule of plant material with roughly 1% actual spermidine, and the amount varies. SPMD-99 contains the pure molecule, verified lot by lot.
You'll usually see it in your hair first, at around 90 days.
Run a panel with immune markers. In a recent clinical study, spermidine reversed declining immune function.
SPMD-99Cellular renewalLinked to nearly 6 years of longer life. Fuller hair, stronger nails, firmer skin.
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Save an ADDITIONAL $10 per month when you subscribe to all three.
3. NMN: NMN-99
Cellular energy
Put your NAD+ back where it was at 25
NAD+ is the longevity molecule. Nothing in you ages well without it.
Your body makes less of it every year starting in your twenties.
NAD+ as a share of the level your body held at 25.
Your NAD+ peaked at 25. It has been falling ever since. In a clinical trial, NMN restored it to the age-25 peak level.
(This applies on average and not to every individual.)Restores the cell’s energy supplyRebuilds NAD+, the coenzyme your cells need for DNA repair and energy
7 proven benefits of NAD+.
Taking NMN every day more than doubles your blood NAD+ levels. Here is what that means for you:
- Longevity.NAD+ fuels sirtuins, the enzymes science links to longer life. When NAD+ drops, sirtuins go quiet.
- DNA repair.NAD+ powers the enzymes that repair tens of thousands of DNA breaks every single day.
- Cellular energy.NAD+ is how your mitochondria make energy and recycle themselves when they wear out.
- Brain.NAD+ fuels your neurons and the repair pathways that keep them working.
- Heart.Your heart beats 100,000 times a day and never gets a night off. NAD+ is what keeps it powered.
- Cellular renewal.NAD+ powers autophagy, the system your cells use to clear debris and rebuild.
- Skin.NAD+ supports the cells that produce collagen and elastin.
More than double the NMN of 4 out of the 5 top-selling competitors.
You can see the actual original lab report for all these products, right here.
NMN per serving.
Per serving, as each brand’s label defines a serving.
In a test of 22 NMN supplements, 14 of them contained less than 1% of the NMN on the label. (Niagen Bioscience, 2021.)
NMN-99 uses only Uthever®, the world’s first patented NMN, verified at 99+% pure beta-NMN, with a manufacturer’s certificate of analysis for every lot.
Most people feel a difference in energy within two weeks.
Run an NAD+ blood test.
NMN-99Cellular energyPowers longevity, repairs DNA and restores energy
FREE SHIPPING IN THE US
Save an ADDITIONAL $10 per month when you subscribe to all three.
4. Urolithin A: Mitopure
Stronger muscles and more stamina, from a compound most people can’t make on their own.
Every cell runs on tiny power plants called mitochondria. Urolithin A helps your cells recycle the damaged ones and build new ones in their place.
In a 4-month trial, adults aged 40 to 65 on 500 mg a day got 12% stronger in the hamstrings.
- Strength
- Stamina
- Cell energy
- Immunity
- Inflammation
Mitopure is the urolithin A used in nearly all the human trials, from the company that ran them.
Not from Opus Longevity. Included because we believe it's the most effective version of urolithin A available.
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5. Omega-3: Momentous
Slower aging, a longer life and a healthier heart.
Among 777 adults aged 70 and over, 1 gram a day for 3 years slowed 3 DNA aging clocks.
People with the most omega-3 in their blood had a 34% lower risk of dying from any cause, and 39% fewer heart events.
- Heart
- Muscle
- Brain
- Skin
- Mood
Momentous is wild fish oil from Norway, NSF Certified for Sport.
Not from Opus Longevity. Included because we believe it's the most effective version of omega-3 available.
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As an Amazon Associate we earn from qualifying purchases.
6. Fisetin: Renue By Science
Of all the plant compounds tested, the strongest at removing old cells your body no longer needs.
As you age, some cells stop dividing but refuse to die. These zombie cells leak inflammation into the tissue around them.
Fisetin clears them out. In a 12-week trial, 200 mg a day lowered inflammation signals, fasting blood sugar and insulin.
- Zombie cells
- Inflammation
- Blood sugar
- Arteries
- Brain
Each Renue By Science capsule holds 150 mg of fisetin in liposomes, tiny fat bubbles, for better absorption.
Not from Opus Longevity. Included because we believe it's the most effective version of fisetin available.
See it at Renue By Science (opens in a new tab)
7. Vitamin D3 and K2: Thorne
Younger telomeres, a stronger immune system, a longer life.
Telomeres, the protective tips at the ends of each strand of DNA, get shorter as you age. In a 4-year trial, they shrank by 20 base pairs on 2,000 IU of D3 a day, and by 160 on a placebo.
D3 helps your gut absorb calcium. K2 makes sure that calcium ends up in your bones, not your arteries.
- Brain
- Immunity
- Blood sugar
- Bones and arteries
Thorne’s D + K2 Liquid is NSF Contents Certified: NSF checked that what’s on the label is in the bottle.
Not from Opus Longevity. Included because we believe it's the most effective version of vitamin D3 and K2 available.
See it on Amazon (opens in a new tab)
As an Amazon Associate we earn from qualifying purchases.
They're best as a stack.
Together, they help you live longer and feel stronger, sharper, and more alive with every passing year.
| BROQSulforaphane | NMN-99NMN | SPMD-99Spermidine | |
|---|---|---|---|
| Role in the stack | Cellular defense | Cellular energy | Cellular renewal |
| Primary mechanism | Activates Nrf2, your master switch for antioxidant and detox genes | Rebuilds NAD+, the coenzyme your cells need for DNA repair and energy | Triggers autophagy, the cleanup process your cells run during fasting |
| What it does inside a cell | Switches on the cell’s defenses | Restores the cell’s energy supply | Clears out the cell’s waste |
| Key pathway | Nrf2/KEAP1/ARE | NAD+/SIRT1/PARP | Autophagy/mTOR/EP300 |
BROQ protects your cells. NMN-99 powers them. SPMD-99 takes out the trash. Your cells need all three.
All three fit into one daily routine.
- In the morning
BROQ On an empty stomach or 30 minutes after a meal
NMN-99 With or without food
- With your last meal
SPMD-99 With food. Start with 1 capsule, then 2 after a few days.
Each one delivers the daily dosages used in the studies that showed its benefits.1
1 With BROQ, you may need to take more than one serving per day to reach these levels.
Flip them overEvery ingredient and every milligram on the back of each package.
BROQ
NMN-99
SPMD-99
Made in California, the right way.
BROQ, NMN-99 and SPMD-99 are each produced in California, in a highly advanced FDA-registered facility that has GMP certification from NSF, UL, and the Natural Products Association, as well as organic and Non-GMO certifications. Independently lab tested for purity and potency.
- FDA-registered facility
- GMP certified
- Certificate of analysis on every lot
- Made in USA
The questions people ask.
Can you take all three together?
Yes. They’re best as a stack, and they work side by side without getting in each other’s way.
Why these over cheaper versions?
Because in this category, cheap usually means you are not getting the molecule you paid for.
BROQ. 25 mg of sulforaphane per serving. More than double the sulforaphane of 18 of the top 20 competitors. BROQ’s capsule opens past the stomach, so the conversion happens where your body can absorb the result.
NMN-99. In a test of 22 NMN supplements, 14 of them contained less than 1% of the NMN on the label. (Niagen Bioscience, 2021.) NMN-99 uses only Uthever®, the world’s first patented NMN, verified at 99+% pure beta-NMN, with a manufacturer’s certificate of analysis for every lot.
SPMD-99. Most spermidine supplements use wheat germ extract: a big capsule of plant material with roughly 1% actual spermidine, and the amount varies. SPMD-99 contains the pure molecule, verified lot by lot.
We built all three to be the best you can buy, not the cheapest.
How soon will you notice anything?
Most people feel a difference in energy within the first two weeks. NAD+ powers every cell in your body, and energy is usually the first change people notice.
In a placebo-controlled study lasting 90 days, spermidine pushed significantly more follicles back into active growth. Hair is usually where people see it first.
Sulforaphane works best taken every day, and the effect builds. The rest of the work happens inside and you will not feel most of it.
If you want to see it rather than feel it, run an ordinary blood panel before you start and another one 4 months in.
What if it’s not for you?
Full refund within 180 days for any reason. No need to send anything back. Email hello@opus.life with your order number, and you get a refund.
Annual subscriptions are fully refundable for 30 days after your first delivery.
When should you take them?
Take BROQ and NMN-99 in the morning, when your body is primed for energy and defense. Take SPMD-99 with your last meal, when your cells naturally shift into repair mode. That said, any time of day works. Consistency matters most.
What is in the capsules?
BROQ. Three things. Broccoli seed extract at 92%, horseradish at 5% for the myrosinase enzyme that converts it, and organic rice hulls at 3% to keep the powder dry.
NMN-99. The capsules are plant based and hold three ingredients: NMN, organic acacia fiber and organic rice hulls.
SPMD-99. Three ingredients. Plant-based capsules holding spermidine, organic acacia fiber and organic rice hulls. No wheat germ. No gluten. Free from the 9 major allergens.
That is the whole list.
How do the plans work?
Each product is its own line in your cart and its own subscription. Subscribe & Save ships and bills it every month until you change or cancel it online. The Annual Subscription is prepaid for 12 months. One-time is one order.
Can you pause or cancel?
Yes, any time, and you do it yourself. Each product is its own subscription. Skip, pause or cancel any one online.
Subscribe & Save. You can skip a delivery, change the date, change the frequency or cancel outright in your account, and none of it needs an email or a phone call.
Annual Subscription. Pause anytime. Annual subscriptions are fully refundable for 30 days after your first delivery.
Is shipping free?
Yes. Free shipping in the US on all subscriptions and on orders over $99.