FROM OPUS LONGEVITY

Have scientists in this Italian village just found the key to living longer?

Scientists in this small town in Italy have found one compound that enables people who take it to live, on average, six years longer than they would without it.

Mike X Franzini

By Mike X Franzini, co-founder and CEO, Opus Longevity

· 2 min read

Opus Longevity 98% recommend 1,643 reviews from verified customers
Brunico from the air: its castle in the foreground, the town’s red and brown roofs, green fields and wooded mountains beyond
Brunico, Italy

In Brunico, a village in the North of Italy, scientists have found a way to extend human lifespan by an average of six years.

The study spanned 20 years, and it included more than 800 people.

It compared 146 different compounds - to see which ones helped people lower their biological age most and stay alive longest.

The one that ranked first … is called spermidine.

Your cells think you’re fasting.

Basically, spermidine makes your body think you’re fasting - without having to skip any meals.

A slice of dark chocolate layer cake on a white plate, lit hard from the side
Have your cake and eat it too.

That - triggers autophagy, which literally means “to eat yourself”.

(Auto means self, and phagy means eat.)

Aging cells eat themselves and get replaced with youthful ones, lowering your biological age.

Nobel Prize, 2016. The prize was awarded for discovering how autophagy works.

This might be the single most powerful longevity supplement ingredient found so far.

Pure spermidine, not extract.

There are a lot of spermidine brands to choose from.

Thing is - most are made from Wheat Germ, which is about 1% spermidine - and varies a lot based on crops.

Golden wheat germ flakes next to a heap of pure white crystalline powder on dark slate
Left, wheat germ extract, which is roughly 1% spermidine by weight. Right, the pure molecule.

Double the spermidine of 4 out of the 5 top-selling competitors

An independent 3rd-party lab tested the other 5 top selling spermidine supplements, along with our product - Opus Longevity SPMD‑99.

The SPMD-99 package: 20 mg per serving of 99+% pure spermidine, 60 capsules

You can download the original lab reports and see for yourself.

See results for the 5 top-selling competitors

An independent 3rd-party lab tested how much spermidine each product contains. Lab reports state that product was received in unopened retail packaging.

See prices below

And here’s the coolest part -

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Why would you NOT give this a try?

How to try it

SPMD-99

The new Gold Standard of spermidine supplements

Opus Longevity 98% recommend 1,643 reviews from verified customers
Add to cart$37.40

180-Day Money-Back Guarantee. No need to send anything back.

180-Day Money-Back Guarantee. No need to send anything back.

You can see the results in your biomarkers. And if you don’t, you pay $0.

Take it daily for four months. If you don’t see results, email us. You’ll get a full refund for all of it. No need to send anything back.

Full refund within 180 days for any reason. Annual subscriptions are fully refundable for 30 days after your first delivery.

Fast & Free Shipping (for subscriptions) Secure Checkout Nothing to send back
  • 99+% pure spermidine
  • Not wheat germ extract (which contains allergens and is about 1% purity)
  • The highest dose in any leading brand
  • We publish independent 3rd-party lab tests of every batch

Deep cellular renewal your body does less of every year.

✓ Pure spermidine, not wheat germ extract. No wheat, no gluten. ✓ 99+% purity. Wheat germ is approximately 1% purity. ✓ More spermidine per serving than any leading brand. ✓ Every batch tested by an independent lab.
The evidence

Linked to nearly 6 years of longer life.

In a 20-year study comparing 146 compounds, spermidine had the strongest link to a longer life of any nutrient measured. Nearly six more years.

Kiechl et al. Higher spermidine intake is linked to lower mortality: a prospective population-based study. American Journal of Clinical Nutrition.

Linked to nearly 6 years of longer life Of 146 compounds tracked for 20 years, spermidine had the strongest link to longer life.
Spermidine, 1st146 compounds
The problem

Inside every cell, the junk is piling up.

Worn-out proteins. Broken machinery. Cellular debris that accumulates faster every year you are alive.

Autophagy is the process by which every cell in your body takes out the trash. Fasting is the famous way to trigger it. But autophagy slows with age, and the junk it once cleared piles up.

auto·phagy /aw-TOFF-uh-jee/ auto self    phagy to eat Your cells literally eat themselves, devouring their own worn-out parts to rebuild fresh.

Nobel Prize, 2016. The prize was awarded for discovering how autophagy works.

A heap of worn-out machine parts on a deep blue surface: chipped brass gears, snapped springs, cracked bearings and sheared bolts

Worn-out parts, piling up. Autophagy clears them, and spermidine is what switches autophagy back on.

The solution

Your cells think you’re fasting.

Your body produces spermidine for one reason: to launch autophagy. The deep cellular renewal that hunts down every piece of debris piling up inside your cells, and destroys it.

It activates the exact same renewal pathways as a prolonged fast. Every cell gets the signal to strip out the old, the broken, the spent, and rebuild from scratch.

No hunger. No deprivation. The full power of fasting, from a molecule your body already knows.

A slice of dark chocolate layer cake on a white plate, lit hard from the side
Have your cake and eat it too. Get the benefits of fasting. Without the fasting.
Spermidine per serving

The highest dose in any leading brand.

21.9 mgper serving in lab tests. The next closest brand delivers 19.0 mg.

Every serving delivers a full 20mg, which meets or exceeds the dosage in every major study linking spermidine to a longer life.

Clean label: only 3 ingredients. Plant-based capsules containing spermidine, organic acacia fiber and organic rice hulls. That is the whole list.

Measured by an independent 3rd-party lab. Tap any brand to see its lab report.

SPMD-99 lab report21.9 mg
Renue By Science® lab report19.0 mg
Nutricost® lab report11.0 mg
Double Wood® lab report10.4 mg
OMRE® lab report9.4 mg
spermidineLIFE® lab report0.7 mg
The SPMD-99 advantage

Pure spermidine, not extract.

SPMD-9999+%SpermidineEvery time
VS
Others (wheat germ)~1%SpermidineVaries

Most spermidine supplements use wheat germ extract, which is roughly 1% spermidine by weight, and it is why two capsules of one brand and two of another can deliver completely different amounts. Plant material varies from harvest to harvest. A pure molecule does not, which is why SPMD-99 is guaranteed to deliver what’s shown on the label.

No wheat, no gluten, free from the nine major allergens.

3HCl formNo wheat germAssay verified

Every batch is tested by an independent 3rd-party lab, proving it delivers what’s promised on the label.

Golden wheat germ flakes next to a heap of pure white crystalline powder on dark slate

Left, wheat germ extract, which is roughly 1% spermidine by weight. Right, the pure molecule.

What renewal does for you

7 proven benefits of spermidine.

  1. Longevity. Scientists tracked 146 compounds over 20 years. Spermidine ranked first for its link to a longer life.
  2. Cellular renewal. Spermidine triggers autophagy, the cellular renewal fasting is famous for. Without skipping a meal.
  3. Hair. Fuller, thicker hair. In a placebo-controlled study, spermidine drove more follicles into active growth.
  4. Heart. Spermidine helps keep your hardest-working muscle running strong.
  5. Skin. Spermidine drives collagen production and strengthens the moisture barrier that keeps skin firm.
  6. Brain. Spermidine crosses the blood-brain barrier and clears the toxic protein buildup that clouds thinking.
  7. Immunity. In a clinical trial, spermidine improved immune function.
Proven in people

In a 90-day human study, more hair in its growth phase.

Your hair follicles have two modes: growing and resting. As you age, more of them rest. Spermidine drives autophagy directly in the scalp, clearing the oxidative damage that shuts follicles down. In a placebo-controlled study, it pushed significantly more follicles back into active growth.

Fuller hair. Stronger nails. Firmer skin. One molecule behind all of it.

Dense, thick hair in extreme close-up, strands catching the light as they emerge from the scalp
A modern threat

You need help cleaning up the microplastics.

Microplastics have been detected in the blood of 77% of healthy adults. Based on recent research, you are likely carrying about 7 grams of microplastics in your brain: the weight of a plastic spoon.

When your cells detect nanoplastics, they try to clear them using autophagy. But plastics jam the system. The recycling machinery stalls, mitochondria get damaged, and inflammation spikes.

Spermidine keeps the autophagy going, isolating the plastic particles and continuing the cleanup. It also triggers mitophagy, clearing the damaged mitochondria so they don’t sap your energy.

Spermidine and sulforaphane are two of the only supplements shown to help remove microplastics from the body.

A crushed plastic water bottle on a white dinner plate, set with a knife and fork

The average person ingests about 20 grams of microplastics every month, the weight of a one-liter water bottle.

Senathirajah and Palanisami, University of Newcastle, Australia, 2019. No Plastic in Nature: Assessing Plastic Ingestion from Nature to People, commissioned by WWF.

Trust the label

Made right, in California.

SPMD-99 is produced in California, in an FDA-registered facility that has GMP certification from NSF, UL and the Natural Products Association, as well as organic and Non-GMO certifications.

FDA-registered facility
GMP certified
Certificate of analysis on every lot
Made in USA

See this lot’s certificate for yourself

A technician in cleanroom gear at a stainless steel encapsulation line
The numbers
21.9 mg
measured in this lot. The label says 20 mg.
99+%
pure spermidine
$37.40
a month, subscribed
See my options

What our customers say

The longevity research was the draw

I first heard about spermidine while reading aging research. I looked up the population study discussed on the page and wanted to explore the ingredient for myself. I am not expecting a supplement to add a specific number of years, but I like the science-led approach.

Peter J.

I am thinking in decades, not days

I take SPMD-99 because I am interested in healthy aging and the research on cellular housekeeping. There is no way for me to judge a longevity outcome after a few months. What I can say is that the dose is clear and the habit is easy.

Howard T.

The headline made me investigate

The longevity language in the video sounded ambitious, so I went looking for the underlying research. I appreciated finding the studies and the explanation of what they do and do not show. That transparency is what persuaded me to try SPMD-99.

Douglas V.

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Questions

The questions people ask.

What does SPMD-99 do?

It takes out the trash, from every cell in your body.

Worn-out proteins. Broken machinery. Cellular debris that accumulates faster every year you are alive. Autophagy is the process by which every cell in your body takes out the trash, and it slows with age, so the junk it once cleared piles up.

Your body produces spermidine for one reason: to launch autophagy. The deep cellular renewal that hunts down every piece of debris piling up inside your cells, and destroys it. It activates the exact same renewal pathways as a prolonged fast.

No hunger. No deprivation. The full power of fasting, from a molecule your body already knows.

Why take spermidine?

It is linked to nearly 6 years of longer life.

In a landmark 20-year study comparing 146 compounds, spermidine had the strongest link to a longer life of any nutrient measured.

Kiechl et al. Higher spermidine intake is linked to lower mortality: a prospective population-based study. American Journal of Clinical Nutrition.

How soon will I feel a difference?

In a placebo-controlled study lasting 90 days, spermidine pushed significantly more follicles back into active growth. Hair is usually where people see it first. The same process that grows hair back makes nails stronger and skin firmer.

The rest of the work happens inside and you will not feel most of it. The label says take it for a minimum of 4 months and beyond. If you would rather measure it than sense it, run a full panel of blood tests before you start and again after 4 months.

Why this one over cheaper spermidine?

Because most spermidine is barely spermidine.

Most spermidine supplements use wheat germ extract: a big capsule of plant material with roughly 1% actual spermidine, and the amount varies.

SPMD-99 contains the pure molecule, verified lot by lot. No wheat. No gluten. Free from the 9 major allergens.

It is also the highest dose in any leading brand. Measured by an independent 3rd-party lab. Tap any brand to see its lab report:

We built SPMD-99 to be the best spermidine you can buy, not the cheapest. It’s up to you which one you take. Just make sure you know what is in it.

What is in the capsule?

Three ingredients. Plant-based capsules holding spermidine, organic acacia fiber and organic rice hulls. That is the whole list.

The spermidine is the 3HCl form, verified at 99+% purity, lot by lot. No wheat germ. No gluten. Free from the 9 major allergens.

SPMD-99 is produced in California, in an FDA-registered facility that has GMP certification from NSF, UL and the Natural Products Association, as well as organic and Non-GMO certifications. The manufacturer’s certificate of analysis for this lot is on this page.

How do I take it?

Start with 1 capsule a day with food. After a few days, move to 2.

Take it with your last meal, when your cells naturally shift into repair mode. That said, any time of day works. Consistency matters most.

You can take up to two servings (4 capsules) a day. Take it every day, for at least 4 months and beyond.

Can I take it alongside BROQ?

Yes, and that is how it was designed.

BROQ is cellular defense. NMN-99 is cellular energy, NAD+ for energy and DNA repair. SPMD-99 is cellular renewal.

Take BROQ in the morning, when your body is primed for energy and defense. Take SPMD-99 with your last meal. They are not competing for anything.

What does shipping cost?

Free, on every subscription, in the United States. There is no minimum.

When am I charged?

At checkout, today. That is true of all three options.

After that, you pay once a month at the same price. The Annual Subscription is one payment today, and nothing else comes off your card for a full year. A single 30-day supply is one payment.

Can I pause or cancel?

Yes, any time, and you do it yourself.

Monthly. Log in to your account to pause a delivery, change your shipping address, switch to a delivery every two months, or cancel outright. Your price stays the same for 12 months. Your schedule does not.

Annual Subscription. Fully refundable for 30 days after your first delivery.

Do I need both NMN-99 and SPMD-99?

No. They do different jobs, and each one works on its own.

The pair costs less for each 30-day supply because we fill and ship one order instead of two.

If you only want SPMD-99, take SPMD-99. Nothing about the shipping or the guarantee changes.

Can I buy a 30-day supply without subscribing?

Yes. There is a one-time 30-day supply option under the two plans.

It is the most expensive way to buy it, and we would rather say so. With a monthly subscription, you pay less for each 30-day supply, ship free, keep that price for a full year, and can pause or cancel at any time.

What if it’s not for me?

180-day money-back guarantee. You don’t even need to send anything back. Email hello@opus.life with your order number, and you get a refund.

Annual Subscription. Fully refundable for 30 days after your first delivery.

One decision

Start taking out the trash.

20 mg per serving of 99+% pure spermidine, the highest dose in any leading brand.

Get started

180-day money-back guarantee. You do not even need to send anything back. Send us an email, you get a refund. Annual subscriptions are fully refundable for 30 days after your first delivery.

We’re here to help

Get a quick answer from a human being.

Emailhello@opus.life
Text(424) 901-2767
Phone(424) 901-2767
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