4.898% recommend
1,643 reviews from verified customers
From every cell in your body. Scientists tracked 146 compounds for 20 years. Spermidine had the strongest link to a longer life.
180-day money-back guarantee. No need to send anything back. Annual subscriptions are fully refundable for 30 days after your first delivery.
Deep cellular renewal your body does less of every year.
The new Gold Standard of spermidine supplements
4.898% recommend
1,643 reviews from verified customers
180-Day Money-Back Guarantee. No need to send anything back.
180-Day Money-Back Guarantee. No need to send anything back.
Annual subscriptions are fully refundable for 30 days after your first delivery.
In a 20-year study comparing 146 compounds, spermidine had the strongest link to a longer life of any nutrient measured. Nearly six more years.
Kiechl et al., 2018. Higher spermidine intake is linked to lower mortality: a prospective population-based study. American Journal of Clinical Nutrition.
Worn-out proteins. Broken machinery. Cellular debris that accumulates faster every year you are alive.
Autophagy is the process by which every cell in your body takes out the trash. Fasting is the famous way to trigger it. But autophagy slows with age, and the junk it once cleared piles up.
Nobel Prize, 2016. The prize was awarded for discovering how autophagy works.
Worn-out parts, piling up. Autophagy clears them, and spermidine is what switches autophagy back on.
Your body produces spermidine for one reason: to launch autophagy. The deep cellular renewal that hunts down every piece of debris piling up inside your cells, and destroys it.
It activates the exact same renewal pathways as a prolonged fast. Every cell gets the signal to strip out the old, the broken, the spent, and rebuild from scratch.
No hunger. No deprivation. The full power of fasting, from a molecule your body already knows.
Every serving delivers a full 20mg, which meets or exceeds the dosage in every major study linking spermidine to a longer life.
Clean label: only 3 ingredients. Plant-based capsules containing spermidine, organic acacia fiber and organic rice hulls. That is the whole list.
Measured by an independent 3rd-party lab. Tap any brand to see its lab report.
Most spermidine supplements use wheat germ extract, which is roughly 1% spermidine by weight, and it is why two capsules of one brand and two of another can deliver completely different amounts. Plant material varies from harvest to harvest. A pure molecule does not, which is why SPMD-99 is guaranteed to deliver what’s shown on the label.
No wheat, no gluten, free from the nine major allergens.
3HCl formNo wheat germAssay verified
Every batch is tested by an independent 3rd-party lab, proving it delivers what’s promised on the label.
Left, wheat germ extract, which is roughly 1% spermidine by weight. Right, the pure molecule.
Your hair follicles have two modes: growing and resting. As you age, more of them rest. Spermidine drives autophagy directly in the scalp, clearing the oxidative damage that shuts follicles down. In a placebo-controlled study, it pushed significantly more follicles back into active growth.
Fuller hair. Stronger nails. Firmer skin. One molecule behind all of it.
Microplastics have been detected in the blood of 77% of healthy adults. Based on recent research, you are likely carrying about 7 grams of microplastics in your brain: the weight of a plastic spoon.
When your cells detect nanoplastics, they try to clear them using autophagy. But plastics jam the system. The recycling machinery stalls, mitochondria get damaged, and inflammation spikes.
Spermidine keeps the autophagy going, isolating the plastic particles and continuing the cleanup. It also triggers mitophagy, clearing the damaged mitochondria so they don’t sap your energy.
Spermidine and sulforaphane are two of the only supplements shown to help remove microplastics from the body.
The average person ingests about 20 grams of microplastics every month, the weight of a one-liter water bottle.
Senathirajah and Palanisami, University of Newcastle, Australia, 2019. No Plastic in Nature: Assessing Plastic Ingestion from Nature to People, commissioned by WWF.
Leading longevity scientists recommend sulforaphane, NMN and spermidine more than any other supplements.
| BROQSulforaphane | NMN-99NMN | SPMD-99Spermidine | |
|---|---|---|---|
| Role in the stack | Cellular defense | Cellular energy | Cellular renewal |
| Primary mechanism | Activates Nrf2, your master switch for antioxidant and detox genes | Rebuilds NAD+, the coenzyme your cells need for DNA repair and energy | Triggers autophagy, the cleanup process your cells run during fasting |
| What it does inside a cell | Switches on the cell’s defenses | Restores the cell’s energy supply | Clears out the cell’s waste |
| Key pathway | Nrf2/KEAP1/ARE | NAD+/SIRT1/PARP | Autophagy/mTOR/EP300 |
BROQ protects your cells. NMN-99 powers them. SPMD-99 takes out the trash. Your cells need all three.
SPMD-99 is produced in California, in an FDA-registered facility that has GMP certification from NSF, UL and the Natural Products Association, as well as organic and Non-GMO certifications.
See this lot’s certificate for yourself
This lot tested at 21.9 mg of spermidine per serving. The label says 20 mg. That is 10% above the claim.
Heavy metals and microbial tests: see the manufacturer’s certificate.
★★★★★
I bought SPMD-99 mostly out of curiosity about healthy aging. After a couple of months, my nails seemed less prone to splitting at the edges. I cannot prove the reason, but it is a welcome little observation.
Nina F.
★★★★★
I first heard about spermidine while reading aging research. I looked up the population study discussed on the page and wanted to explore the ingredient for myself. I am not expecting a supplement to add a specific number of years, but I like the science-led approach.
Peter J.
★★★★★
I used to buy a wheat-germ supplement without being sure how much spermidine I was actually getting. SPMD-99 gives me a specific amount to compare. For someone who reads labels closely, that matters more than a long ingredient story.
Priya S.
★★★★★
I chose SPMD-99 for its connection to cellular renewal research, not because I expected to feel something right away. Lately I have been less sluggish in the early evening. I cannot attribute that confidently to the capsules, but I am encouraged.
Samuel L.
It takes out the trash, from every cell in your body.
Worn-out proteins. Broken machinery. Cellular debris that accumulates faster every year you are alive. Autophagy is the process by which every cell in your body takes out the trash, and it slows with age, so the junk it once cleared piles up.
Your body produces spermidine for one reason: to launch autophagy. The deep cellular renewal that hunts down every piece of debris piling up inside your cells, and destroys it. It activates the exact same renewal pathways as a prolonged fast.
No hunger. No deprivation. The full power of fasting, from a molecule your body already knows.
It is linked to nearly 6 years of longer life.
In a landmark 20-year study comparing 146 compounds, spermidine had the strongest link to a longer life of any nutrient measured.
Kiechl et al., 2018. Higher spermidine intake is linked to lower mortality: a prospective population-based study. American Journal of Clinical Nutrition.
Because most spermidine is barely spermidine.
Most spermidine supplements use wheat germ extract: a big capsule of plant material with roughly 1% actual spermidine, and the amount varies.
SPMD-99 contains the pure molecule, verified lot by lot. Every batch is tested by an independent 3rd-party lab, proving it delivers what’s promised on the label. No wheat. No gluten. Free from the 9 major allergens.
It is also the highest dose in any leading brand. Measured by an independent 3rd-party lab. Tap any brand to see its lab report:
We built SPMD-99 to be the best spermidine you can buy, not the cheapest. It’s up to you which one you take. Just make sure you know what is in it.
Three ingredients. Plant-based capsules holding spermidine, organic acacia fiber and organic rice hulls. That is the whole list.
The spermidine is the 3HCl form, verified at 99+% purity, lot by lot. No wheat germ. No gluten. Free from the 9 major allergens.
SPMD-99 is produced in California, in an FDA-registered facility that has GMP certification from NSF, UL and the Natural Products Association, as well as organic and Non-GMO certifications. The manufacturer’s certificate of analysis for this lot is on this page.
Start with 1 capsule a day with food. After a few days, move to 2.
Take it with your last meal, when your cells naturally shift into repair mode. That said, any time of day works. Consistency matters most.
You can take up to two servings (4 capsules) a day. Take it every day, for at least 4 months and beyond.
Yes, and that is how it was designed.
BROQ is cellular defense. NMN-99 is cellular energy, NAD+ for energy and DNA repair. SPMD-99 is cellular renewal.
Take BROQ in the morning, when your body is primed for energy and defense. Take SPMD-99 with your last meal. They are not competing for anything.
Free, on every subscription, in the United States. There is no minimum.
At checkout, today. That is true of all three options.
After that, you pay once a month at the same price. The Annual Subscription is one payment today, and nothing else comes off your card for a full year. A single 30-day supply is one payment.
Yes, any time, and you do it yourself.
Monthly. Log in to your account to pause a delivery, change your shipping address, switch to a delivery every two months, or cancel outright. Your price stays the same for 12 months. Your schedule does not.
Annual Subscription. Fully refundable for 30 days after your first delivery.
No. They do different jobs, and each one works on its own.
The pair costs less for each 30-day supply because we fill and ship one order instead of two.
If you only want SPMD-99, take SPMD-99. Nothing about the shipping or the guarantee changes.
Yes. There is a one-time 30-day supply option under the two plans.
It is the most expensive way to buy it, and we would rather say so. With a monthly subscription, you pay less for each 30-day supply, ship free, keep that price for a full year, and can pause or cancel at any time.
In a placebo-controlled study lasting 90 days, spermidine pushed significantly more follicles back into active growth. Hair is usually where people see it first. The same process that grows hair back makes nails stronger and skin firmer.
The rest of the work happens inside and you will not feel most of it. The label says take it for a minimum of 4 months and beyond. If you would rather measure it than sense it, run a full panel of blood tests before you start and again after 4 months.
180-day money-back guarantee. You don’t even need to send anything back. Email hello@opus.life with your order number, and you get a refund.
Annual Subscription. Fully refundable for 30 days after your first delivery.
20 mg per serving of 99+% pure spermidine, the highest dose in any leading brand.
180-day money-back guarantee. You do not even need to send anything back. Send us an email, you get a refund. Annual subscriptions are fully refundable for 30 days after your first delivery.
